Osteoporosis, which is one of the most widespread bone diseases, directly affects bone health and causes the gradual destroying of bone tissue and eventually causes fragility. Even if the history of utilizing ultrasound in clinical applications has received high praise in recent years, the field of orthopaedics  has not yet attained its ideal and still lacks the ability to recognize the the issue of osteoporosis prevention. In this article, it is attempted to explore the interaction of the wave in dealing with osteoporosis by identifying the speed index using the transmission of ultrasound waves in the two-dimensional section of the femur bone with the assistance of Abaqus software. For this purpose, four models, including one of healthy quality and three of osteoporotic condition, have been taken into consideration for the femur section. osteoporotic models are obtained by reducing Young's modulus and density of cancellous or bone trabecular. In order to evaluate the speed of ultrasound, simulation of wave propagation has been used in the form of ultrasonic through-transmission test. Results show that with the progress of osteoporosis, the speed of the ultrasound is reduced and a delay is related with the time it takes for the wave to be received by the receiver sensor.